Academic / PhD-level (or peer-reviewed) reports & papers that provide evidence on anger, hostility or negative emotions being linked to biological aging, telomere shortening [ shorter lifespan ] , inflammation, etc

 


Here are several academic / PhD-level (or peer-reviewed) reports & papers (many in PDF) that provide evidence on anger, hostility or negative emotions being linked to biological aging, telomere shortening, inflammation, etc.:

🔍 Key studies & reviews

TitleAuthors / JournalWhat it’s about / Relevance
The associations of hostility and defensiveness with telomere lengthPublished via PubMed CentralStudies shorter telomere length (a biomarker of cellular aging) in people higher in hostility/defensiveness. PMC
High Anger Expression Exacerbates the Relationship Between Age and Metabolic SyndromeBoylan & Ryff, Journals of Gerontology, Series B (PDF available)Looks at how anger expression interacts with age to affect metabolic health, which is related to aging. MIDUS - Midlife in the United States
Anger and Accelerated Epigenetic Aging Among Stress-Exposed IndividualsPMC Open Access articleExamines whether internalizing anger is linked with faster epigenetic aging. PMC
Psychosocial Stressors and Telomere Length (Annual Reviews)Review articleAlthough not exclusively anger, covers how social / psychological stressors accelerate biological aging. Annual Reviews
“Is Anger, but Not Sadness, Associated With Chronic Inflammation …”APA / Psychological AgingShows anger (distinct from other negative emotions) being linked to markers of chronic inflammation. apa.org


Telomere shortening is strongly associated with shorter lifespan. As telomeres (the protective caps at the ends of chromosomes) shorten with each cell division, cells eventually reach replicative senescence—they stop dividing or die.

Shortened telomeres are linked to:

  • Accelerated biological aging

  • Higher risk of age-related diseases (cardiovascular disease, dementia, diabetes, some cancers)

  • Increased overall mortality

So while telomere length isn’t the only factor that determines lifespan, consistent scientific evidence shows that shorter telomeres contribute to earlier aging and reduced longevity.

Here are several peer-reviewed studies (many with full PDFs) showing links between telomere shortening and increased mortality / shorter lifespan:

🔬 Key Studies / Meta-Analyses

  1. Association of Telomere Length With Risk of Disease and Mortality

    • UK Biobank cohort of ~472,000 participants. Found shorter leukocyte telomere length (LTL) correlates with increased risk of overall mortality and disease-specific mortality (cardiovascular, respiratory, etc.). JAMA Network+2JAMA Network+2

    • PDF available. JAMA Network

  2. Telomere Length and All-Cause Mortality: A Meta-analysis

    • Meta-analysis of 25 cohorts, ~121,749 individuals. A standard deviation decrease in telomere length gives ~9% greater risk of all-cause mortality; those in the shortest telomere quarter have ~26% higher hazard compared to those in the longest. ResearchGate

  3. 17-year Follow-up in NHANES (Metabolic Syndrome Group)

    • Followed patients with metabolic syndrome over ~17 years. Shorter telomere length associated with significantly higher all-cause mortality and cardiovascular mortality. PMC+1

    • PDF available. BioMed Central

  4. Telomere Length and Mortality in the Elderly

    • Study of older adults: shorter leukocyte telomeres predict higher mortality. PMC

  5. Rate of Telomere Change Predicts Mortality

    • In a cohort of elderly people (aged 70-79), not just short baseline telomeres, but faster telomere shortening over a few years predicted higher cardiovascular and overall mortality. Aging-US






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